Product
Product Features
NSAIDs
    Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that groups together drugs that provide analgesic and antipyretic effects. Basically, it helps in reducing pain and fever. However, a higher dosage will result in anti-inflammatory effects. NSAIDs are different from steroids. The most prominent members of this group are aspirin, ibuprofen, and naproxen. Most NSAIDS inhibit the activity of COX-1 and COX-2 and thus the synthesis of prostaglandins and thromboxanes is carried out.

    Nonsteroidal anti-inflammatory drugs work on a chemical level. The effects of special enzyme such as Cox-1 and Cox-2 enzymes are blocked by it. These enzymes play a crucial role in the making of prostaglandins. NSAIDs help in blocking the Cox enzyme and thereby stopping the body from making more prostaglandins. This thus helps in easing the swelling and reducing the pain.

    NSAIDs are the safest treatment options when it comes to pain relief. They are way better than the Neurotropic drugs and anti-depressants when it comes to providing pain relief. The primary reason for that is their ability to cause minimum side-effects. NSAIDs don’t have any major side-effects nor do its dosage leads to addiction.
Etoricoxib
    Etoricoxib is also known as non-steroidal anti-inflammatory drugs (NSAIDS) or commonly ‘anti-inflammatories’. Etoricoxib are the safest NSAIDS. In conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, etoricoxib eases the pain and swelling. Etoricoxib works by blocking the effect of a natural chemical known as a COX-2 enzyme. Because of these enzymes, other chemicals such as prostaglandins are produced. Pain and inflammation are caused by prostaglandins.

    Etoricoxib is the best NSAID for pain relief. A selective cox-2 inhibitor with the highest cox1/cox2 selectivity ratio of 106, Etoricoxib is more GI & CV safe in long term use than other conventional NSAIDs. Etoricoxib can be prescribed for long periods too. There are various studies which prove that it can be used for 156 weeks, 138 weeks, 52 weeks so and so forth.

    Etoricoxib has the fastest onset action as it provides the fastest pain relief in just 24 minutes which lasts for 24 hours. It outperforms Ibuprofen which has an onset action of 30 minutes and which only lasts for 2 hours maximum. Thus Etoricoxib not only offers safety but efficacy as well.
Vitamin D3
    Pain occurs due to 2 pathways, inflammatory pathway and neuronal pathway. While Etoricoxib acts effectively on inflammatory mediators to reduce pain by inhibiting release of PGs, Vitamin D3 has a role to play in neuronal pathway as a co-analgesic. Various studies have shown that daily supplementation of Vitamin D3 regulates neurotransmitters like GABA, N methyl N aspartate, NT3, NT4 etc which are pain mediators in neuronal pathway.

    Vitamin D3 helps in neuronal regulation. Vitamin D3 acts as a co-analgesic which is instrumental in treating the root cause of unspecified and vague body pain. Pain mediating neuro-transmitters & receptors like GABA & N-methyl-D-aspartate are modulated by Vitamin D3. It helps in the production of Neural Growth (NGF) to prevent neuro-degeneration. Moreover, Vitamin D3 acts on inflammatory pathways and acts in synergy with Etoricoxib.

    Various recent studies have linked vitamin D3 deficiency to be one of the reasons for unspecified and vague body pain conditions. Daily supplementation of Vitamin D3 with NSAID not only relieves pain effectively but also treats the root cause of pain. Vitamin D3 daily supplementation therefore also manages neurotropic conditions like depression and anxiety and hence there is no need to combine Vitamin D3 with neurotropic drugs.
Indication
    An unspecified and vague body pain is an indication for the use of Vitamin D3 and Etoricoxib. An unspecified and vague body pain can be experienced in the form of fibromyalgia, chronic fatigue syndrome and chronic body pain in osteoporosis. Formerly Neurotropic drugs and anti-depressants were prescribed in the matter of treatment of unspecified and vague body pain.

    However, with the introduction of Nucoxia D3, treatment of unspecified and vague body pain has become much safer. A unique combination of Etoricoxib with Vitamin D3 helps not only to reduce the unspecified and vague body pain but also to treat the root cause of the pain. Nucoxia D3 is the most ideal solution for patients of unspecified and vague body pain conditions caused due to Fibromyalgia, Chronic Fatigue syndrome and Osteoporosis.

    90% of the patients of these types of painful conditions are female. However, in some cases even male population is affected by unspecified and vague body pain for which Nucoxia D3 will be a suitable treatment option. Many studies have suggested that Vitamin D3 has role in managing chronic pain because it acts on neuronal of pain by regulating the neurotransmitters like GABA, NT3 and Neural growth factor.

    Thus, when given with an effective and safe NSAID like Etoricoxib, Vitamin D3 acts as co-analgesic. Also, there are various studies which shows that daily supplementation of Vitamin D3 has been found to be effective in managing pain associated with Fibromyalgia, Chronic Fatigue Syndrome and Osteoporosis.
Dosage
    The therapy of NSAID is advised to be restricted to not more than 15 days due to concern of GI/ CV safety. However, Etoricoxib is a selective cox-2 inhibitor with the highest cox1/cox2 selectivity ratio of 106 which ensures that unlike conventional NSAIDs, Etoricoxib is more GI & CV safe in long term use. There are many doctors across India who has been using Nucoxia for as long as 1 year in some patients without any side-effects.

    Moreover, there are various studies which prove tolerability of Etoricoxib for very long. For examples there are studies which has endorsed it’s usage for 156 weeks, 138 weeks, 52 weeks so and so forth.
Double Granulation Process
    A special manufacturing process called “Double Granulation” process has been used to make both these Etoricoxib as well as Vitamin D3 stable together.

    It is difficult to combine 2 very different and unstable pharmaceutical drugs like Etoricoxib and Vitamin D3, however with research and expertise, these two have been put together which has resulted in a new and never like before remedy for the treatment of unspecified and vague body pain.

    It involves dry and wet granulation. Dry is without using a liquid solution whereas wet involves the addition of a liquid solution. Under dry granulation, primary powder particles are aggregated under high pressure whereas, under wet granulation, fluid beds, tumbling drums and pans are used.